Association Between Thyroid Hormone Imbalance and Cardiovascular Outcomes in the Elderly
1Ali Javed,
1UHS, Lahore
2Usman Ameen
2Al mustafa trust medical center rera bagh AJK
3Umair Shah,
3UHS, Lahore
4Amjad Mirza,
4PIMS Islamabad
5Aroosa Raza,
5PIMS Islamabad
ABSTRACT:
Background: The connection among thyroid hormone imbalance and cardiovascular health in aging populations has been a subject of considerable interest. With aging, alterations in thyroid function can significantly impact cardiovascular physiology, potentially leading to adverse outcomes such as hypertension, dyslipidemia, and increased danger of cardiovascular events.
Aim: Our research aimed to comprehensively evaluate effect of thyroid hormone imbalance on cardiovascular health in aging populations through a systematic analysis of relevant clinical data.
Methods: A retrospective cohort research was led, involving 1000 participants aged 60 and above, with varying degrees of thyroid hormone imbalance. Thyroid function tests, involving TSH, T3, and T4 levels, were measured, and cardiovascular health parameters, such as blood pressure, lipid profile, and incidence of cardiovascular events, were assessed. Statistical analyses, including multivariate regression and correlation studies, were employed to determine the association between thyroid hormone imbalance and cardiovascular health results.
Results: The study revealed a significant association between thyroid hormone imbalance and adverse cardiovascular health outcomes in aging populations. Participants with hypothyroidism demonstrated a higher prevalence of hypertension (63%), elevated LDL cholesterol levels (55%), and increased incidence of cardiovascular events (32%) compared to euthyroid individuals. Conversely, participants with hyperthyroidism exhibited a higher prevalence of atrial fibrillation (42%) and lower HDL cholesterol levels (48%). Furthermore, thyroid hormone levels showed a significant correlation with cardiovascular health parameters, with TSH levels demonstrating a particularly strong association with blood pressure and lipid profile abnormalities.
Conclusion: Thyroid hormone imbalance exerts a notable influence on cardiovascular health in aging populations, with hypothyroidism and hyperthyroidism both contributing to distinct patterns of cardiovascular risk. These findings underscore the importance of thyroid function assessment in the management of cardiovascular health in the elderly population.
Keywords: Thyroid hormone imbalance, cardiovascular health, aging population, hypothyroidism, hyperthyroidism, hypertension, dyslipidemia, cardiovascular events.