Investigation of Chronic Pathogenic Clinical Manifestations Persisting Beyond Three Months Following Negative SARS-CoV-2 Real-Time Polymerase Chain Reaction Testing
Shaim Ali, AIMS Hospital Muzaffarabad AJK
- Aneeza Majeed, Azad jammu And kashmir Medical College MZD
- Dr Haseeb Ahmed, PMC Rawalakot
- Dr Ayesha, MBBS MC Mirpur
- Dr Aneeza Majeed AJKMC Muzaffarbad
- Kawish Ali, AIMS Hospital Muzaffarabad AJK
ABSTRACT:
The precise long-standing effects of COVID-19 on health remain uncertain. Most prior studies focused on post-COVID-19 signs, using extensive medical surveys for comparatively brief durations following recuperation. Our aim was to identify enduring pathological clinical indications and biochemical remnants that persist beyond 12 months after a negative RT-PCR test for SARS-CoV-2.
Amongst the cohort of 140 individuals who had survived COVID-19, with an average age of 37.28 and a male proportion of 53.7%, there was a notable increase in systolic blood pressure (P=0.001). Markers such as erythrocyte sedimentation rate, C-reactive protein, and D-dimer demonstrated higher values in COVID-19 fighters (P<0.0001). COVID-19 survivors also exhibited higher levels of serum lipase, amylase, and albuminuria (P≤0.0001). Regression analysis (adjusted odds ratio, 96% confidence interval) indicated that ESR (P=0.016), hemoglobin concentration (P=0.038), serum lipase (P=0.019), blood urea nitrogen (P=0.004), albuminuria (P=0.047), 26 (OH) vitamin D (P=0.004), and serum uric acid (P=0.006) served as substantial analysts of COVID-19 survivorship (with an overall prediction accuracy of 95.7%).
COVID-19 survivors encountered enduring and noteworthy medical and biochemical changes that demand extensive medical attention and ongoing monitoring for extended durations.
Keywords: COVID-19, Polymerase Chain Reaction (Rt-Pcr), Clinical Indications, Biochemical Remnants.