Comparison between Efficacy of Oral Montelukast versus Inhaled Corticosteroids in Reactive Airway Disease in Children

¹Dr. Aneesa Iqbal, ²Ahmed Haroon, ³Faiza Maqsood, ⁴Dr. Afshan Abbas, ⁵Qasim Raza, ⁶Tabbasum Raja

¹Muhammad Teaching Hospital, Peshawar

²UHS, Lahore

³PIMS, Islamabad

⁴Pharmacology department. Sir Syed College of Medical Sciences for girls.

⁵Mayo Hospital, Lahore

⁶Sir Gangaram Hospital, Lahore

ABSTRACT

Background: Excessive airway disease is an ordinary cause of repeated wheezing and asthma-like symptoms in children. The two important pharmacologic intercede is oral montelukast like a leukotriene receptor antagonist and inhaled corticosteroids are broadly used, but their relative effectiveness remains discussed.

Objective: To contrast the clinical effectiveness of montelukast versus inhaled corticosteroids in children with excessive airway disease.

Methods: A modified study was held in children aged 6–14 years determined with RAD. Patients were randomized into 2 groups: one receiving oral montelukast and the other inhaled corticosteroids for 1214 weeks. Initiating results included symptoms of depletion, frequency of exacerbations, and pulmonary function development.

Results: Both treatments enhance clinical results, though ICS gives superior effectiveness in reduction of exacerbation frequency and enhancing lung function scores. On the other hand, montelukast gives medium control with better complaisance.

Conclusion: Inhaled corticosteroids retain the first-line therapy for pediatric reactive airway disease due to higher effectiveness, even with montelukast may be linked in patients with poor inhaler complaisance or mild disease.

Keywords: Corticosteroids, ICs, Lung, montelukast, inhaler, exhale.